Twinbrook station is located in the southern section of Rockville, one of the largest communities in Montgomery County.

Specifically, it lies to the east of the intersection of Rockville Pike and Halpine Road, the railway's right-of-way splitting the latter in two.

In addition, it calls for the redesign of certain arterial roads in the neighborhood such as Twinbrook Parkway and Parklawn Drive as well as connecting dead-end streets to create a grid, aiding walkability.

[5] Twinbrook is served by an island platform west of the CSX Metropolitan Subdivision tracks, which carry Amtrak and MARC Trains.

Both the east and west sides of the station have bus bays, surface parking, and kiss and ride lots.