[1][9] After having graduated from Swarthmore in 1915, Twining began his professional baseball career with a team in Chester, Pennsylvania.

[14][15] He did not make his debut until over a month after signing with the team, being the closing pitcher in a 10–3 loss to the Brooklyn Robins.

[16] The Cincinnati Post noted that the game "was a nightmare for Red fans" and reported that Twining "had nothing with which to deceive the [Robins] ...

"[17] After being released by Cincinnati, Twining later spent time in 1916 with a team called "Carney's Point" in Delaware.

[19] The following year, he was a member of the Sun team in the Delaware River Shipbuilding League and also saw action with the "Chester Ship club".

[23][24][25] Twining attended Hahnemann Medical School and graduated with a Doctor of Medicine degree in 1919.