[3] [4] [5] Khanna's second book The Legend of Lakshmi Prasad, a collection of short stories, one of which was based on social entrepreneur Arunachalam Muruganantham, was later made into National Award winning feature film, Pad Man with the focus on dispelling taboos around menstruation.

[16] [17] [18] In 2023, she successfully completed her Masters degree [19] [20] [21] and received an exceptional distinction for her final dissertation, and her work getting shortlisted for the prestigious Pat Kavanagh Prize.

[22] [23] In addition to this, Twinkle also launched Tweak India, a bilingual digital media platform for women and supports a number of causes.

Khanna went onto appear in films such as Jab Pyaar Kisise Hota Hai (1998), Seenu (1999), Baadshah (1999) and Joru Ka Ghulam (2000).

[8][1][9] After finishing her Class 12th, she wanted to pursue a career as a chartered accountant and took the entrance examination, but joined the film industry instead due to the insistence of her parents.

[14] The following year she played lead roles in Raj Kanwar's action film Jaan and Lawrence D'Souza's romance Dil Tera Diwana opposite Ajay Devgn and Saif Ali Khan respectively.

[16] While reviewing Dil Tera Diwana, Vijiyan wrote about Khanna: "Unlike her previous movies, she looks really good in all her scenes and she can act well.

[18][19] Her only release in 1998 was Jab Pyaar Kisise Hota Hai, which featured her as Salman Khan's love interest and was a box office success.

[24] In the same year, she acted opposite Saif Ali Khan in Yeh Hai Mumbai Meri Jaan, a romantic comedy directed by Mahesh Bhatt.

[26] Chal Mere Bhai (2000) featured Khanna in a special appearance beside a leading role in the comedy Joru Ka Ghulam, opposite Govinda.

[37] In 2002, Khanna opened her own interior design store in Crawford Market, Mumbai, called The White Window, in partnership with her longtime friend Gurlein Manchanda.

[40] Khanna did the interiors for Rani Mukerji's,[41] Reemma Sen's[42] and Tabu's houses,[43] Kareena Kapoor's Bandra flat in 2008[44] and Poonam Bajaj's design studio.

[51] Khanna is the co-founder of Grazing Goat Pictures and has co-produced the films Tees Maar Khan (2010) and Patiala House (2011).

[60] Penguin Random House have announced that Khanna's book Mrs Funnybones hit the Nielsen bestseller list at number 2 in its first week of sales.

Launched in Mumbai on 18 August 2015, the book reached number 1 on the bestseller chart of Crossword's Kemps Corner store and received praise from readers and press, eventually making Khanna the highest-selling female author in India for that year.

[61][62][63] Khanna's second book The Legend of Lakshmi Prasad, a collection of four short stories, launched in November 2016 sold more than 100,000 copies.

[66] The publisher reported that the book debuted at number 1 on the Nielsen Bookscan All-India Bestseller List and sold over 100,000 copies.

[70] She was also invited to be a part of an eminent panel at the United Nations, New York and also appeared on BBC world Impact show to talk about menstrual hygiene and sanitation globally.