Two-Face has since been substantially adapted from the comics into various forms of media, such as feature films, television series and video games.

His live-action portrayals include Billy Dee Williams in Batman (1989), Tommy Lee Jones in Batman Forever, Aaron Eckhart in The Dark Knight, Harry Lawtey in Joker: Folie à Deux, and Nicholas D'Agosto in the television series Gotham.

In 2009, Two-Face was ranked #12 on IGN's list of the Top 100 Comic Book Villains of All Time.

[2] The Harvey Dent incarnation of Two-Face appears in series set in the DC Animated Universe (DCAU), voiced by Richard Moll.

[12] The Harvey Dent incarnation of Two-Face appears in the Batman: Arkham franchise, voiced primarily by Troy Baker and by Jesse Berry as a child.