[3] Twywell is recorded in the Domesday Book as Twowelle but can be dated back to the Iron Age.

[4] The charter was preserved in the archives of Thorney Abbey, which in the 1050s was one of those controlled by Northman's relation Abbot Leofric of Peterborough.

[5] Manor House Farm dates from 1591 and some of the building material is thought to have come from an old monastery situated between Slipton and Sudborough at a site known as "Money Holes".

The locomotive was of German manufacture, possibly provided by Germany as part of the reparations for World War I.

The area was designated a site of special scientific interest and is a nature reserve and country park.

(See below) [7] Twywell was the birthplace of the bluestocking writer Hester Chapone, née Mulso (1727–1801), whose conduct book Letters on the Improvement of the Mind (1773), addressed to a 15-year-old niece, remained influential and regularly reprinted for over fifty years.

[8] Horace Waller (1833–1896), anti-slavery activist, missionary and cleric, was Rector of the Anglican parish of Twywell from 1874 to 1895.

It forms part of the joint benefice of Cranford with Grafton Underwood and Twywell.

Nearby Twywell Hills and Dales Country Park provides attractive countryside walks.

Twywell Plantation, a wood belonging to the Woodland Trust, lies to the south and west of the village.