She is known for playing Andrea Marino in the first season of Ghost Whisperer, Dr. Tara Lewis in Criminal Minds since 2015, Mother Nature in the final two The Santa Clause films, and voicing Lana Kane in Archer.

[2] She also hosted Ubisoft's E3 press conferences and has lent her voice to the video games Halo: Reach, Gears of War 3, and Watch Dogs.

[11] After briefly working for a San Francisco advertising firm, she toured the country pursuing a comedy career[12] then moved to Los Angeles in 1996.

Tyler has devoted a significant amount of her time to independent projects, including a role in the play Moose Mating, for which she received an NAACP Image Award.

Moving into acting, Tyler featured in Friends as Dr. Charlie Wheeler[15] where she was Joey's and then Ross's girlfriend in the ninth and tenth seasons.

She also made a guest appearance on Kanye West's single "Slow Jamz", which featured Twista and Jamie Foxx.

[21] In 2009, she began her starring role voicing Lana Kane in the FX series Archer, which premiered on January 14, 2010[22] and ran for a total of 14 seasons, ending in 2023.

While Hal Sparks was out of the country, Tyler filled in as the third member of the Stephanie Miller Sexy Liberal Comedy Tour on three shows in August 2011.

In October 2011, it was announced that Tyler would join the cast of The Talk as a permanent co-host, replacing Holly Robinson Peete.

[27] This caused Tyler to respond with a poem about how she has been playing video games "since you were a twinge in the left side of your daddy's underoos.

Tyler's second book, Self-Inflicted Wounds: Heartwarming Tales of Epic Humiliation, debuted in July 2013, later becoming a New York Times bestseller; it was inspired by questions asked of guests on Girl on Guy.

Tyler was also the original voice for the character Daisy Fitzroy in the 2013 video game BioShock Infinite, but her recordings were not used[31] and the role went to Kimberly Brooks.

In June 2015, it was announced that Tyler landed a recurring role on the eleventh season of Criminal Minds as Dr. Tara Lewis.

[15] Although she served as a temporary replacement for Jennifer Love Hewitt, who was on maternity leave,[32] her status was elevated to a main cast member in season 12.