[5] He finished the season with 10 goals and 25 assists,[4] rejoining the Storm in the playoffs capture the J. Ross Robertson Cup as OHL champions.

Bertuzzi led the Memorial Cup with five goals in four games, as the Storm made the final, but lost to the Edmonton Oil Kings to finish second in the tournament.

[14] On October 31, he was suspended two games by the AHL for a slew foot infraction against Kasperi Kapanen of the Toronto Marlies.

On November 7, 2016, Bertuzzi was recalled by the Detroit Red Wings after Thomas Vanek was placed on injured reserve.

[17] On November 15, Bertuzzi was returned to Grand Rapids after appearing in three games for the Red Wings, going scoreless.

[19] He remained with Detroit until December 28 when he was returned to the AHL, appearing in four games, going scoreless, but had not played since November 29 due to an injured ankle.

[26] He recorded his first NHL point assisting on Justin Abdelkader's goal in a 3–1 loss to the New Jersey Devils on December 27.

[35] He played in 71 games with the Red Wings, scoring 21 goals and 48 points before the NHL suspended the season due to the COVID-19 pandemic on March 12, 2020.

[4][36] A restricted free agent in the off-season, the Red Wings and Bertuzzi could not agree on a contract and opted for salary arbitration.

On October 28, Bertuzzi was awarded a one-year, $3.5 million contract by the arbitrator, which the Red Wings signed.

[39] He began the 2021–22 season with four goals against Andrei Vasilevskiy in a 7–6 opening night loss to the Tampa Bay Lightning in overtime on October 14.

[40] He had a second four-point night on November 6 against the Buffalo Sabres, scoring two goals and registering two assists in a 4–3 overtime win.

[42] He missed a month and returned, but had his left hand broken by a shot from teammate Ben Chiarot on November 30 in a game against the Buffalo Sabres.

The Bruins won the game 4–2 over the New York Rangers and Bertuzzi picked up his first point with the team, assisting on Coyle's first period goal.

[4][51] Bertuzzi, considered one of the top unrestricted free agents, was signed to a one-year, $5.5 million contract with the Toronto Maple Leafs on July 2.

[52] He made his Maple Leafs debut in the 2023–24 season opening 6–5 victory over the Montreal Canadiens on October 11.

[4] The Maple Leafs made the 2024 Stanley Cup playoffs and faced Bertuzzi's former team, the Boston Bruins, in the first round.

[4] On July 1, 2024, Bertuzzi signed as an unrestricted free agent to a four-year, $22 million contract with the Chicago Blackhawks.

[60] On April 29, 2019, Bertuzzi was selected to make his international debut after he was named to the Team Canada roster for the 2019 IIHF World Championship, held in Slovakia.

[61] He helped Canada progress through to the playoff rounds before losing the final to Finland to finish with the silver medal on May 26.