He played in Major League Baseball (MLB) for the Chicago Cubs, Colorado Rockies, and San Francisco Giants.

After compiling 20 home runs for the Cubs during the season, on September 19, 2010, in a game against the Florida Marlins, Colvin was hit in the chest with a shard from a broken bat when scoring on a double by Welington Castillo.

[6] On December 8, 2011, Colvin was traded along with DJ LeMahieu to the Colorado Rockies for Casey Weathers and Ian Stewart.

On July 6, 2012, he became the first player to hit two home runs in the same game against pitcher Stephen Strasburg during a 5-1 win over the Washington Nationals.

[7] On May 14, 2016, Colvin signed with the Long Island Ducks of the Atlantic League of Professional Baseball.

Colvin signed a minor league contract with the Los Angeles Dodgers in February 2018.