[15] On March 29, 2016, Higbee attended Western Kentucky's pro day, along with Brandon Doughty, Prince Charles Iworah, George Fant, and 11 other prospects.
He also was the first player selected from Western Kentucky in 2016 and along with Brandon Doughty, and Prince Charles Iworah, made up the largest draft class in the school's history.
[22] Throughout training camp, he competed for the job as starting tight end against Lance Kendricks, Cory Harkey, Justice Cunningham, and Temarrick Hemingway.
Head coach Jeff Fisher named Higbee the third tight end on the Rams' depth chart, behind veterans Kendricks and Harkey.
His first NFL reception came on the first pass of the game of a two-yard throw by quarterback Case Keenum, before he was tackled by Tank Carradine and Eric Reid.
[27] Higbee entered training camp competing for the starting tight end job left vacant by the departure of Lance Kendricks to the Green Bay Packers in free agency.
[31] The Rams finished the 2017 season atop the National Football Conference (NFC) West with an 11–5 record and received a playoff berth.
On January 6, 2018, Higbee started his first NFL playoff game and had an 11-yard reception as the Rams lost to the Atlanta Falcons in the Wild Card Round by a score of 26–13.
[43] During Saturday Night Football against the 49ers in Week 16, Higbee finished with 104 receiving yards as the Rams lost 31–34 and were eliminated from playoff contention.
[48] During the season, Higbee became the Rams' all-time leader in receptions and receiving yards by a tight end, surpassing marks set previously by Lance Kendricks and Billy Truax, respectively.
[50] However, in the NFC Championship against the 49ers, Higbee suffered a knee injury in the first quarter after catching two passes for 18 yards and missed the rest of the game.
On January 14, 2024, Higbee tore his ACL and MCL while trying to catch a pass from Quarterback Matthew Stafford in the fourth quarter of the Rams' NFL Wildcard playoff game against at the Detroit Lions.
[62] On December 22, 2024 in Higbee's first game back from injury, he had one reception that went for 11 yards and a touchdown in the fourth quarter that helped secure the Rams a 19-9 victory against the New York Jets at MetLife Stadium.
[64] Against Philadelphia in the NFC Divisional Playoff, Higbee caught seven passes for 54 yards, including a 4-yard TD in the first quarter of the Rams' 28-22 loss.
The first encounter happened outside of Dublin's Pub, where Higbee stated Alsaleh kept rubbing his head on his and his girlfriend's face multiple times and ignored persisted warnings to stop.
Following the assault, Higbee was quoted as saying "ISIS these nuts,” and “fuck you, go back to your country.” The victim, Nawaf Alsaleh, was found unconscious and unresponsive in the parking lot of the bar and was hospitalized with a brain hemorrhage and concussion.
Judge Steve Wilson accepted a plea agreement where Higbee must complete a pre-trial diversion program, serve 250 hours of community service, and pay restitution to the victim.