Since his trade from the Kings in 2020, Toffoli has also played for the Winnipeg Jets, Calgary Flames, Montreal Canadiens, New Jersey Devils, and Vancouver Canucks.

[2] Growing up, Toffoli attended Birchmount Park Collegiate Institute in Toronto (into which Scarborough had amalgamated in 1998) and Hillcrest High School in Ottawa.

[9] On April 12, 2013, Toffoli was named the recipient of the AHL's Dudley "Red" Garrett Memorial Award for rookie of the year in the 2012–13 season.

[10] On May 8, 2013, Toffoli made his Stanley Cup playoff debut in Game 5 of the Western Conference Quarterfinals against the St. Louis Blues, replacing scratched Keaton Ellerby in the Kings' lineup.

[18] On February 15, 2020, Toffoli became the first player in league history to record a hat-trick in an outdoor game when the Kings defeated the Colorado Avalanche 3–1 during the 2020 NHL Stadium Series.

[20] Toffoli found success on the Canucks' top line alongside J. T. Miller and Elias Pettersson, putting up 10 points in 10 games, including six goals.

When the NHL season resumed for the playoffs, Toffoli would suffer a high-ankle sprain in Game 1 of the qualifying series against the Minnesota Wild.

He continued to enjoy success during the Canadiens' deep run during the playoffs, notably scoring the series-winning goal in the team's second round against the Winnipeg Jets.

[27] While the Canadiens had a historically poor start to the 2021–22 season, Toffoli recorded five goals and 12 assists in his first 26 games, jockeying for the overall points lead with Nick Suzuki.

[31] The trade reunited him with former Kings coach Darryl Sutter and past teammates Trevor Lewis, Milan Lucic, Sean Monahan, Christopher Tanev and Jacob Markström.

[35] Toffoli's scoring drought extended into the postseason, recording only a secondary assist in the first six games of the series, stymied by a stellar performance by Stars netminder Jake Oettinger.

[41][42] Following the disappointing season, the Flames organization saw significant changes in its staff, with both general manager Brad Treliving and coach Sutter departing.

By late June it was reported that several players, including Lindholm, Mikael Backlund, and Noah Hanifin, had indicated they would be unlikely to re-sign with the team following the expiration of their contracts.

On July 1, 2024, Toffoli joined his seventh NHL club, after he signed as a free agent to a four-year, $24 million contract with the San Jose Sharks.

[49] Following the Kings not qualifying for the 2015 Stanley Cup playoffs, Toffoli made his first international appearance with Team Canada, participating in the 2015 IIHF World Championship and winning the gold medal.