Within the range lies the Tyndall Regional Reserve, a nature reserve that is the western buffer zone for the Cradle Mountain-Lake St Clair National Park World Heritage Area.

The Tyndalls were named in 1877 by James Reid Scott on the suggestion of Thomas Bather Moore in honour of Professor John Tyndall, a Fellow of the Geological Society who made important contributions in physics, atmospheric science and geology.

[5][6][7] The Tyndalls were explored for minerals in the early twentieth century, but no significant working mine ever eventuated.

[8][9][10] The Tyndalls lie south east of the Henty Gold Mine, and Hydro Tasmania dam on the upper Henty River and south of Lake Mackintosh, Lake Murchison and Tullah.

In the 2020s proposals for a walking trail in the range were put forward, despite the relative high incidence of extreme weather conditions compared to other locations.