[11] On August 30, 2014, Hill made his debut for the Cowboys and caught a season-high six passes for 62 receiving yards in a loss to the Florida State Seminoles.

[16][17] On December 11, 2014, Oklahoma State dismissed Hill from their football and track teams following his arrest and guilty plea for domestic violence.

General manager John Dorsey had to receive consent from Chiefs' owner Clark Hunt to make the selection and says they thoroughly vetted Hill, which included speaking to the prosecutor that charged him.

[31] Two weeks later, he had a season-high ten catches for 89 yards, helping the Chiefs come back from a 17–0 deficit and defeat the Carolina Panthers by a score of 20–17.

[47] During Week 8 against the Broncos on Monday Night Football, Hill threw the first interception of the Chiefs' season on a failed trick play.

The Chiefs lined up like they were going to try a Hail Mary and Smith threw an underneath check-down pass to Hill who had a convoy of blockers clear enough space for him to maneuvere to the end zone for the touchdown.

[54] In the narrow 22–21 loss to the Tennessee Titans in the Wild Card Round, Hill finished with seven receptions for 87 yards and a 14-yard rush.

[60] After three less-impressive games, Hill again recorded three receiving touchdowns on seven receptions for 142 yards against the Patriots during a Week 6 43–40 road loss.

[62] In the next game on Monday Night Football, Hill recorded 10 catches for a career-high 215 yards (and the most by any NFL receiver at that point in the season) and two touchdowns in a 54–51 road loss to the Los Angeles Rams.

[69] On April 26, 2019, Chiefs general manager Brett Veach announced that Hill was suspended from team activities as a result of the ongoing child abuse investigation.

[70] The NFL announced on July 19 that he will not be disciplined for the investigation because the league felt he did not violate the personal conduct policy.

[75] In the next game against the Broncos, Hill finished with 74 receiving yards, including a 57-yard touchdown as the Chiefs won on the road by a score of 30–6.

[84] Two weeks later in Super Bowl LIV against the San Francisco 49ers, Hill caught nine passes for 105 yards, including a 44-yard catch on 3rd and 15 that sparked the Chiefs comeback en route to the 31–20 victory.

[87] In Week 12 against the Tampa Bay Buccaneers, Hill finished the game with 13 catches for a career-high 269 yards and three touchdowns during the 27–24 victory.

[96] In the Chiefs 38–24 victory in the AFC Championship over the Buffalo Bills, Hill recorded nine catches for 172 yards, including a 71-yard reception.

He was targeted by Mahomes on the Chiefs' last offensive play, but the ball was tipped by safety Jessie Bates into the hands of Vonn Bell.

[121] He was named to his seventh career Pro Bowl and earned first team All-Pro honors for the fourth time.

[122][123] Hill finished the year with career highs in receptions and receiving yards with 119 and 1,710 respectively, and helped the Dolphins to a playoff berth before losing to the Bills in the Wild Card Round 34–31.

[131] In Week 7 against the Eagles, Hill became the second player in franchise history, after Paul Warfield, to score a touchdown in six of the team's first seven games.

[144] Before his season debut on September 8, 2024, Hill was detained by Miami police for a minor traffic violation near Hard Rock Stadium.

[168] The following month, his son was placed into care of child services temporarily as a result of an emergency hearing conducted by the Kansas Department of Children and Families.

[169] On April 24, Johnson County District Attorney Steve Howe released a statement, saying that his office believed a crime had been committed but that the evidence did not allow them to determine the perpetrator, and that the Kansas Department of Children and Families would continue to investigate.

[172] On June 10, reports surfaced that medical investigations showed his son's arm had been broken by accident and in a way that indicated it had happened as he braced for a fall.

[176] On June 18, 2023, the Miami-Dade Police Department announced they were investigating Hill for allegedly assaulting a male employee of the Haulover Marine Center following the two having a verbal disagreement.

[182] On February 23, 2024, model and influencer Sophie Hall filed a civil lawsuit against Hill, alleging that he had broken her leg during a football lesson at his house the previous June when he invited her to run offensive line drills against him.

Steadman Stahl, president of the South Florida Police Benevolent Association, said Hill wasn't being cooperative and that he was "redirected" to the ground after refusing to sit when he was briefly detained.

Florida Governor Ron DeSantis discussed the incident saying "I was pleased to see he did well in the game and it was good for the team, what happened on the field.

Miami-Dade Police director Stephanie Daniels told the Miami Herald that the decision to place the officer on leave came after a review of the body camera footage from the roadside incident.

Despite the incident, Hill played in that afternoon's game against the Jacksonville Jaguars, where he finished with seven catches for 130 yards and one touchdown in a 20–17 win.

Jacob told the media that “Tyreek intends to continue the national movement for necessary police reform that George Floyd’s death started.