He has said in interviews that he was inspired by his older sisters who "brought out the music in me" but did not begin songwriting until his move to California.

In 2000, Wells launched his solo career, playing acoustic shows in Orange County, California.

Wells worked with songwriter and producer Martin Terefe (Jason Mraz, KT Tunstall, James Morrison) and Iain Archer (UK indie artist and Snow Patrol co-writer) in the UK, and Tim Myers (formerly of OneRepublic), David Hodges (formerly of Evanescence) and Matt Scannell (Vertical Horizon) in the U.S.

The song "Losing Ground", one of a handful of production/songwriting collaborations between Wells and Terefe, was written and demoed in less than 3 hours during their first writing session together.

The 2010 independently released EP, Metal & Wood, saw Wells return to his acoustic, singer-songwriter roots.

His fourth full-length album and first since leaving a major label, Where We Meet embraced both sides of Wells' acoustic vulnerability and pop rock irresistibility.

The album's first single, "Freedom", spawned a music video and was used in trailers for Disney's The Odd Life of Timothy Green.

Tyrone and his wife Elina have three daughters named Aria Lian, Ireland Mele, and Taya Aika Neal Wells.