The station is located in the south end of the borough, and is currently only served by Amtrak's Pennsylvanian, which operates once per day in each direction.

A new railroad station building exists at the stop, but it is only currently used as a museum for the Tyrone Historical Society.

Due to the small number of passengers, Tyrone station is a flag stop.

Historically, there had been more Pennsylvania Railroad trains between Pittsburgh and Harrisburg, with many stopping at the station.

[4][5] Greyhound has an intercity bus stop less than 1⁄4 mile (0.40 km) north of the station, at 20 West 10th Street.