It is at the junction of the lines linking Birmingham with Leamington Spa and Stratford-upon-Avon.

The main station building is on a bridge over the tracks, on the Wharfedale Road (B4146).

In 2007–08 Network Rail resignalled the line between Birmingham and Warwick, modified the track at Tyseley and restored platforms 1 and 2 to use.

Two new junctions have been built at each end of the station, which allow non-stopping services between Solihull and Birmingham Snow Hill to cross at 60 mph.

Tyseley is no longer served by Chiltern Railways services as of the May 2023 timetable change.