[2] On 9 October 2021, undefeated WBC and The Ring heavyweight champion Tyson Fury defended his world titles against former WBC champion Deontay Wilder in their trilogy match, when he defeated Wilder via eleventh-round knockout in a widely acclaimed contest that was named The Ring magazine Fight of the Year 2021.

[7][8] Fury reacted to the news, stating on social media that he is "coming home", suggesting that the fight against Whyte will be the first time he will box on U.K. soil since his August 2018 win against Francesco Pianeta.

85,000 of the 90,000 available tickets were sold within the first 3 hours, prompting Fury's promoter Frank Warren to begin the process of applying to the local authorities to expand the capacity to 100,000 fans, which would make Fury-Whyte the largest post-war boxing attendance in the history of the United Kingdom.

Fury continued to dominate the fight, landing a straight right in the fifth round which appeared to momentarily stun the challenger.

Although Whyte was able to beat the count and rise to his feet, the referee deemed it unsafe for him to continue, halting the fight after two minutes and fifty-nine seconds of the sixth round, declaring Fury the winner by sixth-round technical knockout.

[17] This lasted until 20 October 2022, when it was announced that Fury would return to defend his WBC title against Derek Chisora in a trilogy bout on 3 December at Tottenham Hotspur Stadium.