He is the lead vocalist, bassist, pianist, and songwriter of the rock band The All-American Rejects.

As an actor, Ritter appeared as himself on the seventeenth episode of season three in the Fox drama series House which aired in April 2007, he appeared as Dane on Amazon Video's Betas, recurred as rock musician Oliver Rome in the NBC drama series Parenthood, and has had supporting roles in films, including The House Bunny (2008) and Miss You Already (2015).

In 2018, Ritter played recurring characters on two television series on AMC, Preacher and Lodge 49.

[7] Shortly after the release of "Air", Ritter wrote the song "Collide", which was also featured on Parenthood.

He had also been cast in the lead role of singer Gregg Allman in the biopic Midnight Rider, directed by Randall Miller, but the film was halted in production, and ultimately cancelled, due to the death of camera assistant Sarah Jones.

[10] In October 2022, Ritter formed the band Now More Than Ever with guitarist Izzy Fontaine and keyboardist Scott Chesak.