He played in Major League Baseball (MLB) for the Oakland Athletics, San Diego Padres, Texas Rangers, St. Louis Cardinals, and Detroit Tigers.

[6] Ross made 6 appearances (4 starts, 0-1) in 2008 for the Single-A Kane County Cougars of the Midwest League, posting a 4.66 ERA.

[7] In 2009, he began the season with the Single-A Stockton Ports of the California League, starting 18 games, posting a 5-6 record with a 4.17 ERA.

[8] Despite not having pitched above Double-A, Ross made MLB roster while making only 5 spring training appearances.

[7] Ross was one of the A's final cuts in spring training 2011,[10] but was recalled to join the bullpen in early April.

He then shuttled between Triple-A and the A's, starting until the September roster expansion, when he rejoined the parent club as a reliever.

[7] During his tenure with the Oakland Athletics, Ross wore number 66 for the name of the street where he first played baseball, 66th Avenue, located on the northwestern boundary of the Oakland–Alameda County Coliseum.

On November 16, 2012, Ross was traded to the San Diego Padres with minor league infielder A. J. Kirby-Jones for Andy Parrino and Andrew Werner.

[15] He made three starts for the Padres before suffering a left shoulder subluxation in the process of swinging for his first major league hit.

[16] Ross returned from the disabled list on May 5, but was relegated to the bullpen due to concern over his shoulder when batting.

[7] Ross then improved in 2014 with a 13–14 record and 2.81 ERA, with 195 strikeouts (8th in the National League) against 72 walks (8th), and 12 wild pitches (3rd), in 195+2⁄3 innings.

He missed the remainder of the season with a shoulder injury and underwent surgery to relieve the symptoms of thoracic outlet syndrome in October, with the surgeon removing one of his ribs in the process.

[24] Ross was wildly inconsistent in his short stint with the Rangers, giving up 37 walks against 36 strikeouts in 49 innings.

[26] Ross earned the fifth spot in the Padres rotation and was called up on April 3, 2018, to make his first start against the Colorado Rockies.

[7] On January 13, 2020, Ross signed a minor league contract with the San Francisco Giants with an invitation to spring training.

[38] Ross pitched for Team USA in 2007, including the Pan-American Games and the World Port Tournament.

His best pitch is a four-seam fastball at 90–95 mph, and he also features a two seamer (90–95), a slider (84–89), and a changeup usually reserved for left-handed hitters (87–89).

[41] Tyson's younger brother, Joe Ross, was a first round pick in 2011 and pitched for the Washington Nationals from 2015 to 2021.