It was formed in 1963 from part of Orientale Province.
In 1966 it was merged back into the reconstituted Orientale Province.
It roughly corresponds to the modern provinces of Bas-Uélé and Haut-Uélé.
The Uélé region was once home to assimilating kingdoms (not Bantu), which however left only a scattered settlements.
[1] In recent times, Haut-Uélé has been exploited for gold mining.