Uście Solne received town charter from King Kazimierz Wielki, on May 18, 1360.

Uście Solne prospered in the second half of the 14th century, due to salt deposits, mined at Bochnia, and transported here along the Raba river.

Uście Solne remained a river port of local importance until the first partition of Poland (1772).

Annexed by the Habsburg Empire as part of Galicia, it quickly lost its importance after the Austrians built a new Vistula river port at nearby Swiniary.

During World War I, heavy fighting between Russian and Austro-Hungarian forces took place here, and the village has a military cemetery nr.