The following is a list of United States ambassadors to Sudan.

The first chief of mission sent by the United States was Arthur E. Beach, who presented his credentials in March 1956.

In 1973 Ambassador Cleo A. Noel, Jr. was taken hostage and killed by the Black September Organization during the attack on the Saudi embassy in Khartoum.

From 2002 to 2022, the United States posted a sequence of chargés d'affaires ad interim to the country.

Ambassador-level representation resumed in 2022 with the appointment of Ambassador John Godfrey, who served until 2024.