The U.S. Customs House and Post Office, also known as the Escambia County Courthouse, is a historic site in Pensacola, Florida.

From 1885 to 1937, the Escambia County Courthouse was a building on the northeast corner of Palafox and Chase streets.

In 1937 Escambia County, which needed more space, swapped its location for that of the U.S. Customs House and Post Office because the Federal Government, which by then had no more use for a customs house, needed a building site for a new U.S. Post Office and Courthouse.

The county moved into the Blount Building until renovations were done on the old customs house and post office in 1938.

This article about a property in Escambia County, Florida on the National Register of Historic Places is a stub.