It originally sat in Independence Hall in Philadelphia as the United States District Court for the District of Pennsylvania, and is now located at the James Byrne Courthouse at 601 Market Street in Philadelphia.

There are five Eastern District federal courtrooms in Pennsylvania: Philadelphia, Lancaster, Allentown, Reading, and Easton.

The chief judge for the Eastern Pennsylvania District Court is Mitchell S. Goldberg.

[3] At the time of its initial subdivision, presiding judge Richard Peters Jr. was reassigned to only the Eastern District.As of January 3, 2025[update]: Chief judges have administrative responsibilities with respect to their district court.

The chief judge serves for a term of seven years, or until age 70, whichever occurs first.