After Rosenberg, US 90 Alternate passes through Richmond, Sugar Land, Stafford and Missouri City before entering Houston.

A section in Stafford from the Southwest Freeway to Promenade Boulevard (east of Dulles Avenue) is a short controlled access highway similar in design to the one which stretches from Present Street to the South Loop.

These portions were previously a four-lane divided highway with exterior shoulder lanes, crossovers, and at grade crossings with major thoroughfares.

Further north, US 90A splits from South Main Street onto the OST, becoming a six lane boulevard heading east to cross State Highway 288 (South Freeway) with a grade separated street-to-street intersection with Griggs Road, and meets the southern terminus of Spur 5 adjacent to the campus of the University of Houston.

US 90 Alternate ends at the junction with Interstate 610 in northeastern Houston, where Business U.S. Highway 90-U continues northeast on McCarty Street.