The U.S. Post Office and Customhouse in Gulfport, Mississippi is a historic post office and customhouse that was completed in 1910 under supervision of the U.S. Treasury Department, with James Knox Taylor as Supervising Architect.

One of the oldest public or commercial structures in the city, it also has been known as Downtown Station and as Old Main Post Office.

[2] It was listed on the National Register of Historic Places in 1984.

[1] Its NRHP nomination asserted "It is a beautifully proportioned building with elegant and tasteful embellishments and is significant as one of the finest examples of Second Renaissance Revival architecture in Mississippi.

This article about a property in Mississippi on the National Register of Historic Places is a stub.