U.S. Route 12 (US 12) is a part of the United States Numbered Highway System that travels from Aberdeen, Washington, to Detroit, Michigan.

In the state of North Dakota, US 12 extends from the Montana border east to the South Dakota border.

Throughout the state, US 12 is a two-lane undivided highway that runs through Adams, Bowman, and Slope counties in southwest North Dakota.

The speed limit is 65 mph (105 km/h) on rural segments, with slower posted speeds within the cities of Marmarth, Rhame, Bowman, Scranton, and Hettinger.

US 12 meets with US 85 in Bowman, and the routes run concurrently for a short distance through the city.