U.S. Route 150 (US 150) in Illinois is a 267.47-mile-long (430.45 km) east–west highway that runs from US 6 near the Quad City International Airport in Moline to the Indiana state line near Vermilion.

East of Knoxville, it meets IL 97 at a 3-way intersection and then I-74 at a partial cloverleaf interchange.

Just south of where IL 78 branches off west, US 150 suddenly turns southeast.

Just before US 150 proceeds to cross the McClugage Bridge, it meets IL 29 at a parclo.

In Morton, US 150 crosses under I-74 numerous times without a direct interchange.

One of them is in Morton, another south of Deer Creek, and another near Farmer City.

[2] Continuing southeast, US 150 briefly runs concurrently with IL 47 in Mahomet.

As it enters the city of Champaign, it crosses above I-57 with no direct interchange.

[5] In 1936, US 150 extended due northwest from Shoals, Indiana, to the Quad Cities.

[8][9] In 1971, the decision to remove a portion of US 150 from US 67 in Rock Island to I-74 in Danville failed.

[10] However, in 1976, the decision to truncate US 150 from US 67 in Rock Island to US 6 near the Quad City Airport was approved.