It runs 75.04 miles (120.77 km) from U.S. Route 27 (State Road 25) in Four Corners, Lake County, east past Walt Disney World and through Kissimmee, St.

Cloud and Melbourne, to end at State Road A1A in Indialantic, one block from the Atlantic Ocean.

The U.S. Route is assigned the following unsigned State Road numbers: US 192 is a major tourist strip in the area around the Walt Disney World Resort and features numerous timeshare and other resorts; the road includes "mile markers" (though not strictly placed at the exact mile intervals) to help tourists locate businesses.

In the late 1990s, the Osceola Parkway (County Road 522) opened, providing a tolled alternate between Walt Disney World and Kissimmee.

In that area, the density of tourist attractions increases as the road approaches Walt Disney World.

Celebration Avenue heads south to an interchange with State Road 417, which crosses US 192 with no direct access.

Another old alignment - Old Vineland Road - is present in this section, rejoining as US 192 turns back east towards downtown Kissimmee.

This is a major north–south road from Kissimmee north to Orlando, built as an alternate to the Orange Blossom Trail.

2000, John Young Parkway carries U.S. Route 17/92 (State Road 600) southwest out of Kissimmee.

Cloud and Sugar Belt Railway, began at Main Street and Drury Avenue in downtown Kissimmee, heading east on Drury Avenue and Neptune Road, crossing US 192 west of downtown St.

Cloud area, US 192 again begins to turn southeast, running mainly through swampland for the rest of its path to Melbourne.

Another old alignment - Lake Lizzie Drive - begins there, running north of US 192 to its end just west of Alligator Creek.

After the Alligator Creek crossing, yet another old alignment - Old Melbourne Highway, former State Road 500A - splits to the east.

At Holopaw, around the middle of the old alignment, U.S. Route 441 and State Road 15 split off to the south, leaving only US 192 and SR 500 beyond to Melbourne.

From there, the old alignment heads straight east back to the current road, passing the Kempfer Sawmill and the former Union Cypress Railroad.

Soon after the old and new alignments join, US 192 crosses into Brevard County on the original Kissimmee-Melbourne Highway, roughly paralleling the old Union Cypress Railroad.

New Haven Avenue is still maintained by the state east of US 1, and is considered a section of SR 500.

In 1935, SR 24 was extended the other way, from Kissimmee northwest along the Kissimmee-Vineland Road and beyond, ending in Mount Plymouth.

The widening of the portion from SR 535 to Interstate 4 to six lanes went several years behind schedule because of unanticipated drainage complications.