Beginning at the intersection of 4th Street North (US 92 and State Road 687 (SR 687) and 5th Avenue North in St. Petersburg, it runs west of US 19 near the Gulf coast passing through the cities of Seminole, Clearwater, Dunedin, and Tarpon Springs before ending at US 19 in Holiday, Pasco County.

It hugs the Gulf coast, servicing Seminole, Clearwater, Dunedin, and Tarpon Springs before ending at US 19 in Holiday.

originally went south through downtown Clearwater on Fort Harrison Avenue, which becomes Clearwater–Largo Road upon entering Largo.

The original alignment has since been decommissioned by the Florida Department of Transportation (FDOT) and transferred to the cities of Largo and Clearwater.

When this plan was first announced in 2001, it was viewed as good news for commuters and businesses championing the project as a way to turn Clearwater into a walkable community.

Within Holiday and Elfers, the road runs along the right-of-way of a former railroad line before heading to Main Street in New Port Richey, where it secretly makes another left turn before terminating at US 19.

CR 595 can be found again between Hudson and Aripeka, where it crosses the Pasco–Hernando county line along the Gulf of Mexico on its way toward Hernando Beach, only to bypass downtown Hernando Beach and terminate once again with US 19, but this time also with the western terminus of CR 574/Spring Hill Drive.