Before reaching Jackman, the road peaks at the Attean Pond Lookout, a popular rest area, before descending into town.

The road continues through parts of Moose River and Dennistown before reaching the Armstrong–Jackman Border Crossing at Sandy Bay Township.

Parts of Benedict Arnold's expedition to Quebec took place along the route that today make up US 201.

The southern half was later shifted east to start in Brunswick (the realignment may have been done prior to actual signing of the route.)

U.S. Route 201 Alternate (US 201A) is the designation of a former alignment of US 201 in the towns of Skowhegan, Norridgewock, Madison and Anson.

The route is 26.18 miles (42.13 km) long and forms a western loop of US 201, which was rerouted in 1954 to bypass to the east.

US 201A begins in Skowhegan just south of the Kennebec River, at an intersection with US 2, US 201, and SR 104 (which has its northern terminus here).

US 201A begins overlapped with US 2 and the two routes proceed southwest along the southern bank of the river on the way to Norridgewock.

US 201A and SR 8 then turn west, joining the converging routes to cross the river as a four-route concurrency.