U.S. Route 23 (US 23) is a part of the United States Numbered Highway System that runs from Jacksonville, Florida, to Mackinaw City, Michigan.

US 23 enters Scott County at the Tennessee state line south of Weber City immediately north of the northern end of the US 23 freeway that becomes Interstate 26 in Kingsport.

The highways curve north and parallel the Clinch River to Clinchport, where the road meets the southern end of State Route 65 (SR 65) and begins to follow Stock Creek.

After passing through the Devil's Racepath, US 58 and US 421 split from US 23 as Daniel Boone Trail just south of the town of Duffield.

[1][2] US 23 follows Wildcat Creek and becomes a freeway adjacent to Mountain Empire Community College south of Big Stone Gap.

The highways curve north over a rail line and SR 74 before reaching a partial cloverleaf interchange where US 58 Alt.

The U.S. Highway briefly enters the town limits while receiving the north end of the business route, Main Street.

[3][4] The road from Moccasin Gap (now Weber City) south to Tennessee toward Kingsport was added to the state highway system in 1923.

Its third business route runs along portions of Norton Road and West Main Street in Wise.