U.S. Route 250 (US 250) is a United States Numbered Highway that runs from Sandusky, Ohio, to Richmond, Virginia.

U.S. 250's northern entrance into West Virginia is via the Military Order of the Purple Heart Bridge from Bridgeport, Ohio, onto Wheeling Island.

The route additionally co-signs with Interstate 70 and crosses the Ohio River on the Fort Henry Bridge in Wheeling, West Virginia.

Today, it runs from Sandusky, Ohio to Richmond, Virginia, passing its original eastern terminus.

U.S. Route 250 Truck follows Blue and Gray Expressway around the south and west sides of downtown Philippi, avoiding the covered bridge.