U.S. Route 25 (US 25) in the state of Tennessee runs northwest from North Carolina and runs concurrently with US 70 for its entire length until splitting into US 25W and US 25E in Newport.

[1] The Tennessee section of US 25 begins at the North Carolina state line near Del Rio, concurrent with US 70 and unsigned State Route 9 (SR 9).

US 25/US 70/SR 9 then goes through some curves and cross the French Broad River via the Wolf Creek Bridge.

They then begin running along the north bank of the French Broad River, intersect and become concurrent with SR 107, and then enter Del Rio, where SR 107 separates.

US 25/US 70/SR 9 continue northwest to intersect SR 340 before leaving Del Rio.