U.S. Route 35 (US 35) is a United States Highway that runs southeast-northwest for approximately 412 miles (663 km) from the western suburbs of Charleston, West Virginia to northern Indiana.

The highway's southern terminus is in Teays Valley, West Virginia, near Scott Depot, at Interstate 64 (I-64).

As of November 11, 2021, the final West Virginia portion of the highway has been expanded to four lanes, mostly along a completely new route.

The first, partial interchange, providing a westbound exit and an eastbound entrance, is with State Route 7 (SR 7), just outside the village of Gallipolis.

There, US 35 once again meets SR 160, this time at a partial interchange with an eastbound exit and a westbound loop ramp entrance.

Approaching the edge of Rio Grande, the route turns west and then west-southwest, where there is an interchange at SR 325.

Traveling north-northwest and northwest into Jackson County, the expressway configuration continues until SR 327, where there is a grade-separated, one-quadrant interchange, with the connecting road in the southeast quadrant of the junction.

US 35 then turns roughly west, entering Ross County and reaching an interchange with Vigo Road/Watson Road at Richmond Dale.

Turning north and northwest, the section between Richmond Dale and Chillicothe includes a large cut through a 1,000-foot (300 m) ridge and provides westbound motorists with a panoramic view of the Scioto River valley.

Next, US 50 west leaves the concurrency at a partial interchange at Eastern Avenue; there is only a westbound exit and an eastbound entrance.

Then, the US 23 north freeway joins US 35 in a concurrency at a partial-Y interchange; there is an eastbound exit and a westbound left entrance.

Turning northwest, the US 23 north freeway leaves the concurrency at a partial-Y interchange; there is a westbound exit and an eastbound left entrance.

The next, partial interchange, is at Pleasant Valley Road/Egypt Pike with a westbound exit and an eastbound entrance (via Larrick Lane).

Entering Fayette County, the road turns west-northwest, bypassing south of Washington Court House.

As the route continues through flat farmlands, it enters Greene County, bypasses north of Jamestown and south of Xenia.

Several miles later, in Montgomery County, the road opens into a three-lane highway (with five lanes in some parts) each way through downtown Dayton.

It overlaps US 31 for only 4.5 miles (7.2 km), to a partial interchange where it splits off, heading west as a two-lane roadway.

The roadway briefly widens to a four-lane divided highway at a partial interchange with Davis Road, which connects from Kokomo.

Northbound US 35 and westbound US 24 exit the Hoosier Heartland Highway at a split diamond interchange and run concurrently along the interchange's westbound one-way frontage road, having a very short overlap with SR 25 (southbound US 35 and eastbound US 24 run concurrently along the eastbound one-way frontage road, also overlapping SR 25).

After crossing the Wabash River, the overlapped routes have a final interchange where US 24 exits heading due west, while US 35 continues north-northwest.

Soon after US 24 leaves US 35, US 35 narrows back to a two-lane road and travels through the town of Winamac, in Pulaski County.

The route next turns north-northwest until it leaves the concurrency with US 6 northward in Washington Township, near Kingsbury.

Farther northwest, US 35 has its northern terminus where it meets US 20 in Springfield Township, just east of an interchange with I-94, near Michigan City.

In response in 2014, the Indiana Department of Transportation (INDOT) added signage, placed flashing lights on the stop signs, and installed rumble strips.

[8] Originally, US 35 was routed from Charleston, West Virginia, on the north side of the Kanawha River (the current WV 62) to Point Pleasant until the collapse of the Silver Bridge in 1967.

When the new Silver Memorial Bridge was completed in 1969, US 35 was moved to the south side of the river (the former WV 17) away from Point Pleasant, and its southern terminus was in St. Albans, West Virginia, at the junction of US 60.

Before funding was made available to convert US 35 to an expressway, a possibility had been put forward that the route would have been completed as a toll road.

On August 26, 2015, the at-grade intersection with Keystone Furnace Road and McCarty Lane at the Jackson–Lick Township line was converted into a right-in/right-out interchange.

[30][31] At this time the Indiana State Highway Commission authorized the addition of SR 17 between Kokomo and Logansport.

[49][50] INDOT submitted an application in October 2008 to the American Association of State Highway and Transportation Officials (AASHTO) to extend the decommissioning of US 35 to include the entire portion of the roadway from the east junction with US 20, through the US 20/SR 212 interchange, to US 12.