I-155/US 412 then cross the Chickasaw Bluffs into Dyersburg, where they pass along the northern edge of the city and have an interchange with SR 78 (Exit 13).

It then has a parclo interchange with the eastern end of SR 88 before leaving Bells and continuing southeast through farmland to cross into Madison County.

Wright Drive (Exit 85), before coming to an interchange with US 70 (SR 1/Exit 87), where US 412 splits off from I-40 and turns southwest along US 70.

US 412 then splits and turns east at the eastern end of US 412 Bus, and US 412 becomes concurrent with SR 20 again as they leave Jackson as a two-lane highway.

US 412/SR 20 continue east through farmland to the community of Springbrook, where it widens to a 4-lane divided highway and has an intersection with SR 152 just before crossing into Henderson County.

[5] US 412/SR 20 continue east through countryside and farmland and pass through Crucifer before narrowing to a 4-lane undivided shortly before entering Lexington.

[7] The highway has an intersection SR 438 just south of Mousetail Landing State Park before passing through some hills before entering Linden.

The highway then leaves Linden after crossing a bridge over the Buffalo River and continues east to the community of Chestnut Grove, where SR 100 splits off at a Y-Intersection and goes northeast.

US 412/SR 99 then narrows to 2-lanes and continues east to leave the city, though it is still within the city limits, and go through farmland to eventually come to an interchange with I-65 (Exit 46), where US 412 ends and SR 99 becomes signed as a primary highway as it leaves Columbia and continues east.