It follows Pine Avenue through downtown Niagara Falls, spanning 2.12 miles (3.41 km) between New York State Route 104 (NY 104) at its western terminus and US 62 at its eastern extent.

US 62 was shifted onto its current alignment through the city later in the decade, allowing Pine Avenue to become New York State Route 62A in the early 1970s.

Between 10th and Portage Road, a local north–south arterial, US 62 Business passes along the northern edge of the Niagara Falls Memorial Medical Center.

Although this area is mostly commercial as well, it features decorative elements not found west of Portage Road, such as stylized streetlights alongside the roadway.

The district extends for 1.25 miles (2.01 km) eastward to Hyde Park Boulevard (NY 61), where another overhead sign denotes the eastern edge of Little Italy.

[4] Pine Avenue in Niagara Falls was originally designated as part of NY 34 when the first set of posted routes in New York were assigned in 1924.