US 62 begins at the Santa Fe Street Bridge at the Mexico–US border in El Paso concurrent with U.S. Route 85.

US 62 continues to run along E. Paisano Drive and has a short overlap with State Highway 20, which both enters and leaves via a traffic circle.

Just north of I-10, US 62/180 leave E. Paisano Drive and begin to run along Montana Avenue, passing just south of El Paso International Airport.

After leaving El Paso County, the highway runs through sparsely populated areas and the town of Pine Springs near Guadalupe Mountains National Park.

US 62 runs along the Marsha Sharp Freeway through a heavily developed area of southwest Lubbock before leaving US 82 at State Highway 114.

US 62/SH 114 run through the heart of the city on 19th Street before becoming Idalou Road at Martin Luther King, Jr. Boulevard.

US 62 ends its overlap with US 83 just north of the Prairie Dog Town Fork Red River and exits the state into Oklahoma a few miles west of Hollis.