U.S. Route 6 (US 6) is a United States Numbered Highway, stretching from Bishop, California in the west to Provincetown, Massachusetts on the East Coast.

The Nevada portion crosses the center of the state, serving the cities of Tonopah and Ely, en route to Utah and points further east.

At Warm Springs, State Route 375 (SR 375), also known as the "Extraterrestrial Highway", departs to the southeast and US 6 assumes a northeasterly alignment across the Reveille, Pancake, Grant, and White Pine ranges.

East of Ely, US 6 and US 50 cross the Schell Creek Range, known for verdant forests and meadows and for a large mule deer and elk population.

The highway descends to Spring Valley, then crosses the Snake Range at Sacramento Pass, north of Nevada's second-highest mountain, Wheeler Peak, where a branch road accesses Great Basin National Park.

Although US 50 has the nickname "The Loneliest Road in America", US 6 has a solid case for the title; as Tonopah and Ely are the only cities it goes through in the 306 miles (492 km) it traverses in Nevada, with a combined population of just over 6,500.

In contrast, US 50 boasts Stateline and the rest of the South Lake Tahoe area in Nevada, Carson City, and Fallon, along with other smaller communities.

From Majors Place to the Utah state line southeast of Baker, the highway was concurrently routed with SR 14.