With a few exceptions, US 7 is mainly a two-lane rural road winding through the Berkshires, largely parallel to the Housatonic River.

The three routes meet just north of the Lenox census-designated place boundary, with US 7/US 20 becoming a four-lane surface road until Pittsfield.

At a signalized intersection with Housatonic Street, US 20 makes a left turn to continue west toward Albany.

[2] US 7 leaves downtown Pittsfield as a two-lane surface road and continues as a rural highway with occasional three-lane stretches for climbing the grades along the Berkshires.

The road passes Williams College and crosses the Hoosic River one last time before entering Vermont.