US 83-S) is a business loop of US 83 in the Lower Rio Grande Valley region of Texas.

The highway serves as the main street for many communities in the area, such as McAllen, Mission, San Juan, Alamo, and more.

Leaving the city, the highway serves the town of La Feria, before entering into Mercedes.

In the city of Weslaco, the highway passes by the South Texas College - Mid-Valley Campus.

After the intersection with FM 2062, development along the route begins to drop, traveling mainly through more rural areas of the city.