Starting at the Mexican border in San Luis, US 95 acts as the main highway north through Gadsden, Somerton and Yuma before arriving in Quartzsite.

The route between Quartzsite and San Luis was also the first segment of SR 95 to be commissioned by the Arizona State Highway Department.

U.S. Route 95 (US 95) begins at the United States Customs and Immigration checkpoint station on the Mexican border in San Luis, Arizona.

From there, the route proceeds north to Urtuzuastegui Street, where it becomes a one-way pair around downtown San Luis.

[2] On the north end of downtown, Cesar Chavez Boulevard provides direct access to Arizona State Route 195 (SR 195).

Continuing north from San Luis, US 95 enters the rural landscape of southwestern Yuma County.

The highway goes almost perfectly straight north, paralleling the Colorado River and international border to Gadsden.

On the east side of Somerton, US 95 angles to the northeast for short distance, before turning straight north at County 15th Street.

[3][4] East of I-8 Business, US 95 crosses over the Union Pacific Railroad on an overpass before arriving at a diamond interchange with Interstate 8 (I-8).

[2] After passing the main campus of Arizona Western College, US 95 curves north through Blaisdell and exits the Yuma metropolitan area.

[3] Near Dome, US 95 intersects with an early alignment of the old main highway between Yuma and Phoenix, before crossing the Gila River over a bridge.

SR 95 continues north on Central Boulevard to Lake Havasu City which is home to the London Bridge, while US 95 heads left onto Main Street.

[5][8] The history of U.S. Route 95 in Arizona dates back to a network of primitive wagon roads between Quartzsite and San Luis.

This was a route extensively used by Native Americans, Spanish missionaries, United States Army personnel during the Mexican–American War, and prospectors heading to California during the 1848 gold rush.

[17] What had started out as a simple county road between the Colorado River and Quartzsite was now the main highway from Los Angeles to Phoenix.

[8] Now a fully maintained state route, SR 95 was one of several highways funded by the Works Progress Administration (WPA) projects during the Great Depression.

[20][5] In July 1939, the Yuma County Board of Supervisors passed a resolution to pave SR 95 between US 80 and the McPhaul Bridge.

[26] Improvement of SR 95 re-commenced on July 29, 1949, when a contract was awarded to two separate private contractors repave part of the highway 35 miles (56 km) north of Yuma.

At the time, 16th Street served the old Panther Field airport and the Silver Spur Rodeo Grounds.

The US 95 extension had been requested by both California and Arizona earlier that year and approved by the American Association of State Highway Officials.

Most of US 95 from the north end of downtown San Luis to Araby Road east of Yuma was given up by ADOT in stages.

[45] Despite the fact ADOT no longer owns US 95 between Yuma and San Luis, the designation is still recognized along the abandoned route.