In early March 2009, Fountain Valley Regional Hospital was fined $25,000 by the California Department of Public Health after a nurse gave a patient oral medicine intravenously.

[2][3] In late August 2012, Fountain Valley Regional Hospital was fined $25,000 by the California Department of Public Health,[4] after a nurse improperly removed a gastrostomy tube from a patient.

[13][14] In early July 2020, a complaint was filed against Fountain Valley Regional Hospital by the National Union of Healthcare Workers to the California Department of Public Health.

[20][21][22] In late October 2022, registered nurses and other healthcare workers at the hospital approved a strike, for a new contract that would address staffing shortages, safety issues and to replace outdated equipment.

[25][26] On February 1, 2024, UCI Health which is part of the University of California, Irvine agreed to purchase Fountain Valley Regional Hospital from Tenet Healthcare.