In December late 2012, Los Alamitos Medical Center was dropped by Health Net, after Tenet Healthcare wanted a higher reimbursement rate.

[4][5][6] In late October 2020, employees belonging to SEIU United Healthcare Workers West threatened a 1-day strike at the hospital due to COVID-19 safety measures.

[9][10] In late August, caregivers approved a new contract for hire pay and benefits, ending their strike.

[11][12][13] On February 1, 2024, UCI Health, part of the University of California, Irvine agreed to purchase Los Alamitos Medical Center from Tenet Healthcare.

[14][15][16] On March 27, UCI Health officially took over the management of Los Alamitos Medical Center[17][18][19] and rebranded it to UCI Health – Los Alamitos.