The hospital has 156 pediatric beds,[1] is affiliated with the University of California, Los Angeles David Geffen School of Medicine, and is a member of UCLA Health.

[5] UCLA Mattel Children's Hospital features an ACS verified pediatric level 1 trauma center.

[12] Large donations for the hospital have also come from celebrities throughout Hollywood including Gwyneth Paltrow and Alexandra and Sean Parker who raised $2.5 million from various events.

[17] The hospital operates an American Academy of Pediatrics verified level IV neonatal intensive care unit[18] with the capacity of 22 beds for critically ill newborns.

The units are designed to provide the feeling of a normal life, assisting young patients in dealing with difficult diagnoses and long stays in the Medical Center.

The musicians presented an autographed guitar to be hung on the walls of the center,[21] and the program launch was followed by a fund-raising event on November 5.