Thus far, Italy and Spain have been the most successful nation in the competition, with their representatives winning respectively three of the twelve editions.

8 associations have never entered a team as of the 2025 Regions' Cup: Austria, Denmark, Norway, Kosovo, Cyprus, Iceland, Faroe Islands, and Gibraltar.

One aspect of the Regions' Cup that is different from most other international club tournaments is the hosting of games.

As teams play each other once in the preliminary and intermediary rounds, in contrast to the more common two-legged fixtures, each group has all its matches held in one particular region.

In most football tournaments, the host nation or city is decided by the governing body before qualification begins.