UFC 118: Edgar vs. Penn 2 was a mixed martial arts event held by the Ultimate Fighting Championship on August 28, 2010 at the TD Garden in Boston, Massachusetts, United States.

[5] On July 23, Sakara's original opponent, Jorge Rivera suffered a broken arm in training and was replaced by Gerald Harris.

[7] A bout between Nate Marquardt and Rousimar Palhares was moved to UFC Fight Night 22 and promoted to the new main event.

On August 5, it was announced that Terry Etim had suffered a broken rib in training and was pulling out of his bout with Joe Lauzon.

[12] On August 25, Dana White announced that the winner of the Florian vs. Maynard fight would be guaranteed the next shot at the lightweight title.