UFC 208: Holm vs. de Randamie was a mixed martial arts event produced by the Ultimate Fighting Championship held on February 11, 2017, at the Barclays Center in Brooklyn, New York.

[7] The bout eventually did not materialize as Holloway had some consideration (nagging injuries and the desire to spend Christmas with his family) about fighting only two months after UFC 206.

[11] A flyweight bout between Ian McCall and Neil Seery was originally scheduled for UFC Fight Night: Mousasi vs. Hall 2.

[17] A heavyweight contest between Derrick Lewis and Travis Browne was scheduled to take place at this event, but was moved a week later to headline UFC Fight Night 105.

However, on January 26, Sullivan was pulled from the card after being notified by USADA of a potential anti-doping violation stemming from an out-of-competition sample collected earlier this year.

[20] Luis Henrique was expected to face Marcin Tybura, but was pulled from the bout on February 1 due to NYSAC concerns related to a corrective eye surgery he underwent almost a year before.

His positive test was caused by clomiphene citrate, which "he was using in a therapeutic dose under the care of a physician to treat a medical condition," USADA said in a statement.