UFC 227: Dillashaw vs. Garbrandt 2 was a mixed martial arts event that was produced by the Ultimate Fighting Championship and held on August 4, 2018, at the Staples Center in Los Angeles, California.

[4] A UFC Flyweight Championship rematch between current champion Demetrious Johnson and 2008 Olympic gold medalist in freestyle wrestling Henry Cejudo also co-headlined the event.

[6] Derek Brunson was expected to face The Ultimate Fighter: Brazil 3 heavyweight winner Antônio Carlos Júnior at the event.

[10] A middleweight bout between Thiago Santos and UFC newcomer Kevin Holland was created to fill the vacant spot on the main card.

However, Lopez pulled out of the bout on July 24 due to an undisclosed injury and was replaced by promotional newcomer Montel Jackson.