UFC 53: Heavy Hitters was a mixed martial arts event held by the Ultimate Fighting Championship on June 4, 2005, at the Boardwalk Hall in Atlantic City, New Jersey.

The event was broadcast live on pay-per-view in the United States, and later released on DVD.

This event was originally scheduled to take place at the Yokohama Arena in Japan with an Interim Heavyweight Championship bout between Andrei Arlovski and Mirko Filipović serving as the main event.

[1] Initially, former champion Ricco Rodriguez was slated to contend for the Heavyweight Championship, but withdrew from the bout, citing complications with his training camp.

[2] Headlining the card opposite of Interim Heavyweight Champion Arlovski, instead, was Miletich protégé Justin Eilers.