UFC 63: Hughes vs. Penn 2 was a mixed martial arts (MMA) event held by the Ultimate Fighting Championship on September 23, 2006.

The event took place at the Arrowhead Pond in Anaheim, California and was broadcast live on pay-per-view (PPV) in the United States and Canada.

Penn, who defeated Hughes in a championship fight in 2004, and was beaten by St-Pierre at UFC 58.

In fact, the Penn loss was Hughes' only defeat in his last twenty fights.

The Quad-City Times reported that Pat Miletich expressed outrage that the UFC had apparently scheduled this event alongside a bout he had forthcoming in the IFL, which caused him to miss cornering Hughes and Pulver, fighters whom he coaches, in their UFC matches.